Carbohydrazide is a white crystalline powder with hygroscopicity. It can be used as a chemical intermediate, deoxidizer for water treatment, etc. It is toxic to a certain extent and irritates the eyes, skin and respiratory tract.
CAS: 497-18-7
Content: ≥99%
Appearance: white crystalline powder
Production capacity: 500 tons/year
Packaging: 25 kg cardboard barrel
Standard: Enterprise export standard
Use: Widely used in water treatment, medicine, herbicide, plant growth regulator, dye, etc.

The following is the synthesis method of carbohydrazide:
Reaction of phosgene with hydrazine hydrate:
The traditional synthesis method is to use phosgene and hydrazine hydrate to react, but because phosgene is a highly toxic substance, it pollutes the environment, and has high safety operation requirements and complex process conditions, which limits the production and development research of this product.

Reaction of dimethyl carbonate with hydrazine hydrate:
Carbohydrazide is synthesized by reacting "green chemicals" dimethyl carbonate with hydrazine hydrate. This method does not use the highly toxic phosgene of the traditional route. It is an environmentally friendly synthesis route with mild reaction conditions, short reaction time, high yield, simple operation, and easy industrialization. The yield can reach 85.2%.

Synthesis of procarbazine using p-methylbenzaldehyde as starting material:
P-methylbenzaldehyde is used as starting material, dibromocyanuric acid and isopropylamine are added, and p-methylbenzamide is obtained after reaction at room temperature; p-methylbenzamide is dissolved in an organic reagent, N-bromosuccinimide and an initiator are added, heated to reflux, and the solvent is removed after the reaction is completed, and procarbazine is obtained through multiple steps of reaction.

Synthesis catalyzed by Grinard reagent and sulfoxide oxidation:
Grinard reagent is used as the starting material, and the synthesis is performed by chemical reduction. During the process, non-toxic catalysts are used to oxidize sulfoxides to improve the reaction efficiency, which can achieve the green synthesis of carbazide derivatives.